Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

Primary TargetBlocking the formation of contractile microfilaments

Caution

Poor quality DMSO will cause degradation of the product, so high quality DMSO is recommended.

General description

Cell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.

Cell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Tanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.Cairns, M.T., et al. 1991. J. Biol. Chem.266, 8176.Nowak, D. 1990. Biomed. Biochim. Acta49, 353.Wang, F., et al. 1990. Biochem. Biophys. Res. Commun.171, 543.Edwards, S.W., and Lloyd, D. 1988. FEBS Lett.227, 39.

Packaging

5 mg in Alu drum

Reconstitution

Following reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.

Warning

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)